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9) revealed no discernible asymmetry, indicating that considerable publication bias is unlikely in the studies evaluating the association between the greater odds of having COPD and current e-cigarette use

Tobacco is the leading cause of preventable death responsible for cancers, heart disease, stroke, and lung disorders

Philip Morris knew that many smokers would compensate for the differences in such low tar cigarettes by smoking more cigarettes, covering holes in the filter, inhaling more deeply, holding smoke longer in their lungs, smoking more of the tobacco rod or otherwise changing their smoking to get more tar or nicotine