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Use of Pharmacogenetics in Nicotine Addiction Treatment Identification of genes involved in the inheritance of specific smoking phenotypes may strengthen the selection of treatment options tailored to individual genotype ( Microglia as Therapeutic Target for the Treatment of Nicotine Addiction We speculate that neurodevelopmental changes may be modulated by pharmacotherapy targeted to activate change in microglial phenotype which may promote brain homeostasis and a neuro-adaptation that favors decreased dependence on nicotine thus microglia are a promising therapeutic target that need to be explored

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