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In 2 meta-analyses, the OR for tobacco cessation of nicotine gum versus placebo was 1.66 (95% CI,1.62-1.85) in one and 1.63 (95% CI, 1.60-1.82) in the other.33,34 These figures are independent of the duration of therapy, the intensity of the psychological help the patient received, and the location where the tobacco cessation program took place.33,34 Sufficient evidence exists to recommend the use of 4 mg nicotine gum over 2 mg gum in highly dependent smokers scoring 7 points or higher on the Fagerstrm test (OR = 2.67

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