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Abbreviations CSC: Cigarette smoke components TMAO: Trimethylamine oxide AMPK: Adenylate-activated protein kinase ACC: Acetyl-coenzyme A carboxylase HMG-CoAR: 3-hydroxy-3-methyl glutaryl coenzyme A reductase DLRG: Dual Luciferase Reporter Gene assay RTPCR: Reverse Transcription-Polymerase Chain Reaction CYP7A1: Cholesterol 7-hydroxylase TNF-: Tumor necrosis factor-alpha ox-LDL: Oxidized low-density lipoprotein NF-B: Nuclear factor-kappa-B HDL-C: High-density lipoprotein cholesterol LDL-C: Low-density lipoprotein cholesterol TC: Total cholesterol TG: Triglycerides AST: Aspartate aminotransferase ALT: Alanine aminotransferase CAT: Catalase SOD: Superoxide dismutase MDA: Malondialdehyde FC: Free cholesterol SCFA: Short-chain fatty acids AI: Atherosclerosis index HCL: Hydrochloric acid TEM: Transmission electron microscope SRA: Sequence Read Archive References Kushi LH, Byers T, Doyle C, Bandera EV, McCullough M, McTiernan A, et al