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rxlist.com (Tofranil ) Keywords Mixed Direct & Indirect Acting Sympathomimetic Ephedrine Trade Name: generic Drug Class: Direct & Indirectly acting Sympathomimetic Mechanism of Action: Indirect Release of Presynaptic Norepinephrine : Although ephedrine has agonist properties on alpha and beta receptors, its primary mode of action is achieved by its indirect tyramine-like mechanism to displace norepinephrine from storage vesicles (Solanki et al, 2014