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Smoking activates the reward areas of your brain, like the nucleus accumbens, that cause you to release feel-good chemicals, like dopamine

Steve Jobs was the marketing person." [249] He is listed as either primary inventor or co-inventor in 346 United States patents or patent applications related to a range of technologies from actual computer and portable devices to user interfaces (including touch-based), speakers, keyboards, power adapters, staircases, clasps, sleeves, lanyards, and packages

Someone living a normal life might not feel anything, and thats the big problem

If you want a deeper consumer-level explanation of how compounds can work together, Cannavine's guide to the entourage effect is a useful companion read