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The delivery of n-MP in the breakfast coffee may then tune that response to the first cigarettes of the day, decreasing the response of the upregulated HS receptors and perhaps increasing the activity of the LS receptors that will respond to the full dose of nicotine

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Reversibility of the smokingcortical thickness association Controlling for pack-years, gender and exact age at scanning (Model 4), positive associations were shown between cortical thickness at age 73 years and number of years since smoking the last cigarette (Figure 4a and Supplementary Table S3)