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95% CI: 1.172.98, p=0.009) were significantly higher among those with a depression/anxiety comorbidity compared to those who reported no symptoms of MDS, anxiety or comorbidity

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These cardiovascular effects are also due to the stimulation of sympathetic neurotransmission by nicotine, which stimulates catecholamine release by activation of nicotinic acetylcholine receptors localized on peripheral postganglionic sympathetic nerve endings