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3.4 Effects on other tissues and organs 3.4.1 Renal effects Two randomized trials evaluated the short-term effects of e-cigarette use at the urinary level in former tobacco smokers and current nicotine e-cigarette users (at least 1 year)

Treatment with nicotine-containing e-cigarette aerosols increased PD-L1 expression ( Figure 1 ) compared with nicotine-free treatment containing only the base elements propylene glycol and vegetable glycerin ( Additionally, in vitro and human studies have shown that e-cigarette aerosols can induce changes of PD-L1 expression in monocytes ( Figure 1 ) compared with controls

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One study recruited high school students from Johannesburg, South Africa [24]