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When nicotine enters the body via smoking, vaping, or nicotine replacement therapies, it is metabolised by the liver into a primary byproduct called Cotinine

Geiger, F

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In addition, they wrote, sales data might not reflect actual consumption, because all purchased products might not be used by the consumer because of loss, damage, or tobacco cessation. And because per person estimates of tobacco consumption are not exact, the authors point out that an upward trend in tobacco consumption does not necessarily mean that more Americans are using tobacco products