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According to the WHO, about 80% of lung cancer deaths are caused by smoking

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8.5 Geriatric Use A combined single- and multiple-dose pharmacokinetic study demonstrated that the pharmacokinetics of 1 mg varenicline given once daily or twice daily to 16 healthy elderly male and female smokers (aged 6575 years) for 7 consecutive days was similar to that of younger subjects

We therefore synthesized an analytical standard and developed a precise liquid chromatographytandem mass spectrometry (LC-MS/MS) assay (25) to quantify the level of CR in NSCLC tumor tissue