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At this low price, the Sinaloa and Jalisco Cartels in Mexico, which are responsible for producing the majority of illicit fentanyl being trafficked in the United States, have been using xylazine as an adulterant to increase their profit, since its psychoactive effects reduce the amount of fentanyl or heroin needed to be included in a psychoactive powder mixture

This gradual approach has a significantly higher success rate than abrupt cessation