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The overdose risk arises when there is a potential mismatch between the potency of the residual drug and the recipients tolerance. To conduct the study, the researchers observed people in their own environment in 2022, conducting face-to-face interviews with 34 participants who were recruited from syringe service programs

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L.s 2008 study, Neurobiology of nicotine addiction: implications for smoking cessation treatment., Nicotine addiction operates through the alpha4beta2 brain receptor, triggering dopamine release for pleasure and mood effects