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(Some pioneers did voice a concern over cigarette cough and possible correlations to heart disease.) One thing everyone seemed to agree on, however, was that it ruined the mind, creating the cigarette fienda deplorable soul whose habit sap[ped] the moral and mental life of its devotee. The theory that regular cigarette smoking invariably turned the user homicidal was so widespread that it became a regular part of the insanity defense: 1899: George W

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Using qRT-PCR, we validated the down-regulation of selected genes in NHBE cells from three different donors upon e-cig treatment

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