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The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), provides explicit criteria to diagnose SUD, emphasizing significant impairment or distress as a result of persistent drug use

The fetal lung, during its developing stage, is unable to protect itself against inhaled foreign substances as efficiently as an adults which in turn may reduce the ability of the respiratory and other systems to protect themselves against other environmental insults, leading to an increase in the potential for disease

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Smoking increases risks of liver diseases