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Smokers tend to compensate by smoking more deeply or more intensively to acquire their required nicotine dose

For context, a published case study described a 21-year-old who experienced severe cardiovascular effects from 15 legitimate extra-strength pouches (10.9 mg each) over 12 hours

However, more common and less easily worked materials, such as basalt and sedimentary rocks, were also used to make pipes throughout the precontact era (30)

Descriptive studies about implementation of overdose prevention and naloxone distribution to ED patients at risk for opioid overdose have been reported, indicating feasibility and acceptability of overdose prevention and naloxone distribution from the ED to patients at risk of opioid overdose, though systematic prospective studies of ED overdose prevention and naloxone distribution have not been published [58, 59]