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doi: 10.1016/j.healun.2011.01.710

When exploring changes of model fit in further models (Table S3, additional file 1), we found considerable improvement of the model fit only by additional adjustment for the ratio of cotinine/3OH-cotinine (adjusted R 2 men 0.40, women 0.41)

Even though smoking is legal, it doesnt mean that its safe, or that it is less harmful than illegal drugs