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Structural impact of chronic cigarette smoking: meta-analytic procedures To identify areas of convergent gray matter decreases across studies, we performed a coordinate-based meta-analysis using the revised version [44, 45] of the activation (in this application, Anatomic) likelihood estimation (ALE) algorithm [26, 46] as implemented in GingerALE v2.3.4 ( ALE is a voxel-wise approach for combining neuroimaging results across a collection of experiments/contrasts and thereby identifying locations of statistically significant spatial convergence

The study further explains that a woman may find it more difficult to quit smoking due to a female sex hormone called progesterone

These channels are responsible for regulating agonist affinity, ion selectivity, desensitization, and downstream signaling 2

Kensler, T