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Methods This is a prospective study of 204,953 individuals aged 45 years sampled from the general population of New South Wales, Australia, who joined the 45 and Up Study from 20062009, with linked questionnaire, hospitalisation, and mortality data to mid-2012 and with no history of cancer (other than melanoma and non-melanoma skin cancer), heart disease, stroke, or thrombosis

Countries such as the U.S., the U.K., France, China, Japan, and Italy are the major markets for e-cigarettes