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Short-Term Dietary Causes of (Transient) LES Dysfunction Fat, chocolate, peppermint, onions, coffee, decaffeinated coffee and overdistention of the stomach are all believed to cause heartburn by decreasing the pressure of the lower esophageal sphincter and increasing the number of relaxations of this sphincter

45,46 TAMs compose 50% of the total cell population in situ 47 and are primarily derived from cytokine-recruited macrophages that are secreted by TME stromal cells and cancer cells, and include CCL2, CCL5, and CSF1

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