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Miller GC, McDermott R, McCulloch B, Fairley CK, Muller R: Predictors of the prevalence of bacterial STI among young disadvantaged Indigenous people in north Queensland

Regarding target organ effects, IQOS emitted much lower levels of harmful and potentially harmful constituents (HPHCs), induced lower cytotoxicity on normal primary human bronchial epithelial cells, and exerted lower overall biological impact (3 to 15 times lower than CS) as induced from systems toxicology analysis 60

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This has led to criticism from lawmakers, including US Senate Minority leader Chuck Schumer, that the company is targeting young people