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In UCSF's CANDIDE study, Leila Mohammadi, MD, PhD, lead clinical investigator, found that chronic cannabis smokers had similar vascular functional defects to those of chronic tobacco smokers, including poorly functioning arteries, and blood serum that inhibited important properties of cultured endothelial cells (the inner lining of blood vessels)

People mainly consume nicotine through traditional cigarettes and other tobacco-based products, as well as vaping

Endogenously methylated CpG dinucleotides are the preferred sites for G to T transversions, accounting for more than 50% of such mutations in lung tumors

Lew Pliamm, Medical Director of the Polyclinic Family and Specialty Medicine Facility, lecturer at the University of Toronto, and an expert on smoking cessation