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This question is particularly relevant for those who suffer from erectile dysfunction and wish to optimize their treatment

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It wrecks the vessel lining (endothelium) and starves it of nitric oxide The inner lining of your arteries, the endothelium, is not a passive pipe it actively releases nitric oxide , the signal that relaxes the spongy erectile tissue (the cavernosal smooth muscle) inside the penis and tells the small penile arteries to open, so blood can pour in and stay trapped