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The chemical composition varies between different types of cigarette smoke: mainstream smoke (MS), which is inhaled into the lungs

In addition, the results were obtained with adjustment for a wide variety of potential confounding factors, including age, physical activity, alcohol intake, body mass index, estimated glomerular filtration rate, diabetes, hypertension, and dyslipidemia

Major regulations include the WHO FCTC Protocol, the EU Tobacco Products Directive (TPD), and country-specific anti-illicit trade laws requiring track-and-trace systems.