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Biochem Biophys Res Commun 509:514520 Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello MR, Carotenuto A, De Feo G, Caponigro F, Salomon DS (2006) Epidermal growth factor receptor (EGFR) signaling in cancer

[41] One of the primary features of the more recent generation of devices is that they contain larger batteries and are capable of heating the liquid to a higher temperature, potentially releasing more nicotine, forming additional toxicants, and creating larger clouds of particulate matter

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Gateway Effect: There is an ongoing debate over the "gateway effect," which suggests that e-cigarette use may lead to smoking initiation among non-smokers, particularly adolescents