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This analysis was conducted using the following model: Cortical thickness= b 0 Intercept+ b 1 Gender+ b 2 Exact_Age_At_Scanning+ b 3 Number_Of_Years_Since_Last_Cigarette+ b 4 Pack-Years+error Results Demographics The mean age (means.d.) at MRI was 72.70.74 years for those that never smoked, 72.70.76 for ex-smokers and 72.70.63 for current smokers