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A separate study found similar results suggesting an increase in MUC5AC protein levels in culture human bronchial epithelial cells exposed to PG:VG aerosols [37] as well as an increase gene expression for several inflammatory markers including cytokines interleukin-6, interleukin-8 and matrix metalloproteinase-9 (MMP-9), known to play a role in the pathogenesis of COPD [37]

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This guideline was developed following the GRADE approach.21 We adhered to Appraisal of Guidelines for Research and Evaluation (AGREE II), Guidelines International Network (GIN), and Guidance for Reporting Involvement of Patients and the Public (GRIPP-2) reporting guidance.83 85 More information about the task forces methods is available on the task force website ( Evidence review and development of recommendations The recommendation was informed by 2 evidence syntheses that addressed the benefits and harms of smoking cessation interventions

She said, Its been almost a year.