The investigators received funding support from the National Institute of Environmental Health Sciences, the National Heart, Lung, And Blood Institute and the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health under Awards Number R01HL145053, R21ES034512, R21ES029345, R56HL158730, R21HD105187, and 2R56HL145053
Carcinogenic Chemicals in Tobacco Smoke Tobacco smoke constitutes more than 4,000 compounds, of which over 70 with carcinogenic activities, such as polycyclic aromatic hydrocarbons (PAHs), nitrosamines, aromatic amines, and others ( N -dimethylnitrosamine (DMN, also known as N -nitrosodimethylamine), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and N -nitrosonornicotine (NNN) ( N -nitrosamines and tobacco-specific nitrosamines (TSNAs) can attack DNA at the O6-position of guanine forming DNA adducts O6-methylguanine and O(6)-[4-oxo-4-(3-pyridyl) butyl]guanine (O6pobG)
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