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In order to overcome tobacco addiction, a person needs strong social support, an article on nicotine dependence from Mayo Clinic explains

Recently, it was reported that nicotine upregulated the transcription of miR-200b in VSMCs [53]

Children have an increased risk of ear infections, severe asthma, lung infections, and death from infant death syndrome

Defendants argued that it was implausible for consumers to expect a safer cigarette, because a reasonable consumer would read the disclaimer stating that no additives does NOT mean a safer cigarette. Likewise, they argued that a reasonable consumer knows that menthol cigarettes contain menthol, so would understand that the no-additive term didnt cover menthol