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Compared with traditional meta-analysis using linear mixed effect models, MR-BRT relaxes the assumption of a log(linear) relationship between exposure and risk, incorporates between-study heterogeneity into the uncertainty of risk estimates, handles estimates reported across different exposure categories, automatically identifies and trims outliers, and systematically tests and adjusts for bias due to study designs and characteristics

4,7,8 Once a cigarette is lit, still more chemicals are formed in the burning process that werent present in the growing and manufacturing stages

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This reduces the chances of successful conception