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This well-known cohort study established many accepted risk factors for CHD, such as high blood pressure, diabetes, imbalances in lipids like cholesterol, and smoking, and continues to inform our understanding of factors that affect heart health

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doi:10.1371/journal.pmed.1000216

In addition to these top three, smoking is also linked to a number of other cancers, an increased likelihood of getting more colds and infections, diabetes, osteoporosis and hip fractures, problems in pregnancy, difficulty with erections, stomach ulcers, gum disease, and the list goes on