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Call your doctor at once if you have: signs of heart problems, such as chest pain, trouble breathing, or feeling like you might pass out signs of psychosis, such as hallucinations, new behavior problems, aggression, hostility, or paranoia signs of circulation problems, such as numbness, pain, a cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes a seizure muscle twitches (tics) changes in your vision

This legislation ushered in a major paradigm shift, allowing opioid maintenance treatment to be delivered outside of methadone clinics

Stead M, Ford A, Angus K, MacKintosh AM, Purves R, Mitchell D