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Fruit flavors are particularly popular among younger consumers, while tobacco flavors appeal to those transitioning from traditional cigarettes

There are also some studies reported that the EGFR mutation in NSCLC could increase the expression of PD-L1 protein, and TKIs could reduce the amount of PD-L1 protein, the signaling pathways referring to this phenomenon are PI3K-AKT, STAT3, NF-B, and MEK-ERK signaling pathways (39)