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The transition period, which will allow products to be sold off in accordance with current regulations, is likely to last until the end of September 2024

Nicotine induces proliferation, migration, and tube formation in endothelial cells

Similar to other flavor additives, menthol has been shown to reduce vascular endothelial function by impairing nitric oxide bioavailability and increasing inflammation in aortic endothelial cells, with higher concentrations resulting in a comparable proinflammatory state as other flavors such as cinnamon and eugenol (clover) [60]