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There are "very important considerations, starting with legal considerations, about getting this right as we move forward in the rulemaking," FDA Center for Tobacco Products director Mitch Zeller said at a briefing

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Finally, the sample size used here exceeds that of previous studies of the combined effects of nicotine and caffeine in regular users (eg, 9-19 participants) and nonusers of nicotine (eg, 10 participants), but may nonetheless have limited study sensitivity

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