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A recent randomized control trial ( N = 864) demonstrated that Astodrimer, when applied every other day for 16 weeks following antibiotic therapy, was associated with a 20% reduction in recurrent BV compared to placebo during 16-week follow up ( Of the products discussed, Astodrimer and dequalinium chloride have the most evidence of benefit in BV, however neither are available in the United States

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According to data from the United Kingdom and the United States, between 1% and 2% of children are abused every year

The tar content of the products ranges from 6 to 12 mg, employing technologies like laser perforation and natural plant flavoring