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1 SATURDAY, JULY 14, 1883 Reprinted in JAMA Centennial Issue July 8, 1983 The Official Organ of the American Medical Association

Methods The methodology for comparative quantitative risk assessment was based on a previous study conducted for compounds in alcoholic beverages 20 with the exception that probabilistic exposure estimation was conducted 65,66,67

4,8 Disrupted Sleep There are numerous sleep-related issues and disorders which have been linked to smoking cigarettes including: 4 Insomnia Sleep apnea Breathing issues at night Poor sleep quality In fact, smokers are 47% more likely to experience sleep-related disorders than non-smokers

At least 57 days