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The challenges associated with decreased immunogenicity of NP vaccines as compared to VLP vaccines can be partly addressed by adjusting the carrier to the desired antigen, based on factors such as size, surface charge, shape and hydrophobicity (46, 47, 50)

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##### Michael LaFaive is director of the Morey Fiscal Policy Initiative at the Mackinac Center for Public Policy, a research an educational institute headquartered in Midland, Mich

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