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yet this first generation of AD had an unfavorable adverse effect profile that has improved significantly with the advent in the late 1980s of selective serotonin reuptake inhibitors (SSRI) and, some years later, of serotonin and noradrenaline reuptake inhibitors (SNRI) and others like mirtazapine, trazodone, agomelatine and bupropion [4]

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