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For topical application he uses tobacco leaves, either as a cataplasm or processed with other plants as an ointment or in the form of a medicated shower (bao de plantas)

Clinical Study: Nicotine Pharmacokinetics of THS Single Use of a Regular or a Menthol Stick Compared to CIG Nicotine pharmacokinetic profiles of the Tobacco Heating System 2.2, cigarettes and nicotine gum in Japanese smokers

Archived from the original on 17 February 2003

From this point on, for some centuries, several administrations withdrew from efforts at discouragement and instead turned the tobacco trade and cultivation into sometimes lucrative government monopolies