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Key clinical features commonly observed in cannabis dependence include: Strong craving or urge to use cannabis even when use is inappropriate Unsuccessful efforts to cut down or control use, often with repeated relapse Increasing priority on cannabis, with a reduction in participation in social, recreational, or occupational activities Time spent obtaining, using, or recovering from cannabis use at the expense of other responsibilities Continued use despite awareness of persistent or recurrent physical or psychological problems likely caused or exacerbated by cannabis Tolerance, where increased amounts are needed to achieve the desired effect Note: Tolerance may be present, but is not required for the uncomplicated specifier Although withdrawal, a physiological syndrome following cessation, can occur with cannabis, F12.20 is designated for cases without documented withdrawal

You may need an additional day or two to regain strength

No significant differences in Th17 cell percentages were detected between Gpr15 / and Gpr15 +/+ mice under these conditions (Supplementary Fig