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Therefore, we aim to test a secondary hypothesis that baseline nicotine metabolite ratio (NMR) will moderate the experimental treatment effect, such that the benefit of dose titration will be greater in those participants who are rapid metabolizers of nicotine, and the final titrated dose they reach will be higher on average than the slow metabolizers

To address this gap, this study presents a larger case series of 17 patients who developed AEP as a result of smoking, with an aim of enhancing our knowledge of its triggers, clinical presentation, and outcomes

But smoking doesnt just cause cosmetic changes

linking tobacco purchases to such cards may be largely unproblematic technically or politically, he writes, citing Singapore as an example