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Remarkably, these nanoparticles were found to impede the invasive and metastatic potential of cancer cells by modulating the expression levels of MMP-2, a key enzyme involved in the degradation of extracellular matrix components and a facilitator of cancer cell dissemination (237)
Key glucose metabolism processes involved in PD include glucose transport, glycolysis, the tricarboxylic acid cycle, oxidative phosphorylation, the pentose phosphate pathway, and gluconeogenesis
117 Another example is that the AMPs, human -defensins, can specifically bind to fibronectin (FN) to block the adhesion and transfer of integrin 51 mediating endothelial cells to fibronectin, and block the proliferation and apoptosis of endothelial cells mediated by vascular endothelial growth factor (VEGF), that is, human -defensins inhibit tumor angiogenesis in many ways, thereby exerting its anti-cancer effect
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