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Skin bacteria transferred from fingers to the stopper can contaminate the vial over time, and contamination shortens usable life dramatically

Majlth, Z., Annus,

But if someone has opioid use disorder (OUD) and is taking large amounts of medications or has a history of OUD, that can affect how they react to anesthesia

For example, referral to psychiatrists may be helpful since ME/CFS seems to coexist with anxiety disorders, symptoms of ME/CFS overlap with Major Depressive Disorder (MDD), and patients with severe ME/CFS may also be at risk of developing secondary MDD (36, 532)