FSP1, known as a member of the apoptosis-inducing factor (AIF) family, is a key component of a non-mitochondrial coenzyme Q (CoQ) antioxidant system in the cytomembrane reported to counter lethal peroxidation and ferroptosis independently of the canonical glutathione-based system Xc /GPX4 axis (Bersuker et al
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Methods Materials GSH, GSSG, 2-mercaptoethanol, ophthalmic acid, S -methylglutathione and yeast glutathione reductase (GR) were obtained from Sigma-Aldrich, HEDS was from Alfa Aesar, GSSCys from Toronto Research Chemicals and NADPH was from Gerbu
Signed informed consent was obtained from all the study participants