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N-carbamylglutamate markedly enhances ureagenesis in N-acetylglutamate deficiency and propionic acidemia as measured by isotopic incorporation and blood biomarkers

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A model of intracellular antigen possibly targeted by non-HLA antibodies is the glutathione S-transferase theta 1 (GSTT1) protein, a member of an enzyme superfamily, involved in cellular detoxification pathways, that represents a barrier against the damaging effects of oxidative stress ( As for other recently described donor-recipient gene polymorphism mismatches, such as the collision genotype at the LIMS1 locus ( In the present study, we retrospectively evaluated donor/recipient GSTT1 genetic profile and the kinetics of GSTT1 antibodies in a population of pediatric, non-sensitized kidney recipients systematically monitored for HLA antibodies throughout the post-transplant period, with the aim of analyzing their role in kidney graft outcome