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Gastrointestinal symptoms (more common with oral preparations): Mild nausea or upset stomach Diarrhoea (typically with very high doses) Other effects: Headache, particularly when treatment is first initiated Dizziness or light-headedness Skin reactions such as mild rash or itching Temporary reddish discolouration of urine (chromaturia) after hydroxocobalamin injections, which is harmless It is important to note that many symptoms attributed to B12 supplementation may actually represent the body's response to correcting a deficiency

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Some older human studies explored DSIP in people with sleep issues and suggested possible effects on sleep structure or daytime function

There are two main forms of B12 supplements: Cyanocobalamin is an inexpensive and stable form that is used in most fortified foods and supplements and is suitable for most people