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A replication study [10] also found that children with autism tended to have lower levels of mercury in their baby hair than did typical infants

Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration

This could give it broader therapeutic potential for: As of 2025, Dihexa has not yet entered large-scale, double-blind, placebo-controlled clinical trials for widespread human use