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In clinical studies, individuals using Tirzepatide achieved greater weight losssometimes over 20% of their body weightthan those on other treatments

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A 2025 meta-analysis pooling three trials (878 participants) confirmed the pattern: significantly greater weight loss than placebo about ~14% of total body weight on average with no significant rise in overall adverse events [6] [7]

However, for conditions like pernicious anemia or post-gastric surgery, injections remain the gold standard