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FIGURE 1 2 The role of sleep in regulating free radicals in the brain: from Reimunds free radical flux theory to modern insights Reimunds free radical flux theory of sleep, proposed in the 1990s, received significant attention for suggesting that ROS accumulate in the brain during wakefulness, when energy consumption is high, and are subsequently cleared during sleep through a scavenging process that also suppresses their production (Reimund, 1994

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This indicates that the transporter system significantly contributes to mediating BBB integrity and permeability of carrier mediated transport (Table 2)